![]() ![]() ![]() Chronic buspirone treatment decreased the amplitude of wheel-running rhythms, lengthened the duration of the active phase and advanced the phase angle of entrainment.Īttenuated photic phase shifts in buspirone-treated hamsters were accompanied by decreased phosphorylation of ERK and CREB. Buspirone administration at midday produced non-photic phase advances in wildtype but not 5-HT 1A receptor knockout mice. These findings suggest that buspirone affected the circadian system in a manner similar to the 5-HT 1A/7 agonist (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide, primarily through the 5-HT 1A receptor, and suggest that therapeutic use of buspirone to manage anxiety may impact circadian function.
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